IV.01 Glioblastoma

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PIV.01.e1 Gliosarcoma (silver reticulin impregnation, x40). Mixed tumour composed of islands of glioblastoma separated by numerous sarcomatous bands rich in reticulin fibres. Problems may occur for differential diagnosis from a desmoplastic reaction, i.e. a reactional proliferation of connective tissue following invasion of the leptomeninges and the vessel walls by the glioblastoma.